Wash & dry hands. Lubrication before anal insertion is suggested. Immediately after removal from package, using your clean & dry finger, insert 1 suppository at bedtime, continue for 7 days, though symptoms may have already subsided. May insert 1 suppository after your morning bowel movement, if needed. Most infections clear up between 3 to 7 days with treatment. If symptoms persist, please consult your physician. Do not use in cases of constipation or active diarrhoea.