Use as a general analgesic following your morning bowel movement and/or administered before bed to help restore comfort & speed healing process. Discontinue use when symptoms have subsided. With clean & dry hands, insert 1 suppository into the anus, immediately after removing from the package. If symptoms persist after 3 days of use, consult your doctor immediately. Prevention: Anal fissures may be due to constipation. Diet & lifestyle changes can help support relief from chronic constipation.